Scott has been a student of consciousness since his honors thesis on that topic at the University of Arizona in the 1970s under the tutelage of Dr. Andrew Weil. Following medical school, Scott studied Jungian therapy and acupuncture while working as a primary care physician in a rural area for four years. MDMA-assisted psychotherapy became a facet of his practice before this medicine was scheduled in 1985. He then completed a psychiatry residency at Columbia program in New York. Scott studied cross-cultural psychiatry and completed a child/adolescent psychiatry fellowship at the University of New Mexico.

Scott has published four books on holistic mental health including the first integrative psychiatry textbook for this field in 2001. His pediatric mental health textbook was published in 2014. Scott is a past President of the American Holistic Medical Association and a past President of the American Board of Integrative Holistic Medicine.

In 2010 he founded Wholeness Center in Fort Collins. This innovative clinic provides cross-disciplinary evaluation and care for all mental health concerns. Scott serves as a site Principal Investigator and therapist for the Phase III trial of MDMA-assisted psychotherapy for PTSD sponsored by the Multidisciplinary Association for Psychedelic Studies (MAPS). He has also published numerous articles about his research on cannabidiol (CBD) in mental health. Currently, Scott works extensively with ketamine-assisted-psychotherapy. He lectures all over the world to professional groups interested in a deeper look at mental health issues, safer tools, and a paradigm-shifting perspective about transformative care.